Pressured Metered Dose Inhalers (pMDI) Analysis

A metered dose inhaler is an inhaler device with specific doses that delivers a specific dose of active substance with each breath. Methylene diphenyl diisocyanates (MDI) consist of a suspension or dispersion of one or more active ingredients in the propellant, or a mixture of propellants or a mixture of solvent and propellants.

A major issue with MDIs, a limitation in the use of such aerosols, is the biohazard nature of their propellants. Chlorofluorocarbon (CFC) propellants are known to harm the environment. Therefore, hydrofluoroalkane is preferred as an alternative compound for chlorofluorocarbons.

The role of the propellant in a methylene diphenyl diisocyanate (MDI) system is to provide the pressure necessary to atomize the drug formulation into micron-scale droplets. Pressurized metered dose inhalers (pMDI) are a type of MDI that works based on pressurized propellant in the aerosol chamber. The advantage of MDIs is accurate and repeatable dosing that minimizes errors.

The first pressurized metered dose inhaler (pMDI) was used in 1956. Previously, asthma patients had trouble managing their condition, and medications were often taken by mouth.

Metered dose inhalers are hand-held aerosol inhalers that use a propellant to deliver a therapeutic agent. Because the device contains a pressurized metal can, they are known as pressurized MDIs or pMDIs.

Pressure metered dose inhalers (pMDI) have been introduced for the convenient and safe multi-dose use of asthma medications. The key components of these devices (propellants, formulation, metering valve, and actuator) all play a role in creating the spray and determining drug delivery to the lungs. Therefore, a pMDI device requires adjustment of formulation, metering valve size, and actuator nozzle diameter to achieve the required spray characteristics and fine particle dosage. Breath-actuated pMDIs, breath-coordinated pMDIs, spray rate modifiers, and spacer devices are useful for patients who cannot properly use a conventional pMDI device. Modern pMDI devices contain propellants that do not damage the ozone layer and are used for various therapeutic indications.

Our company also provides pressure metered dose inhalers (pMDI) analysis services with its trained and expert staff and advanced technological equipment, among the numerous test, measurement, analysis and evaluation studies it provides for businesses in various sectors.