Chloramphenicol Analysis (Antibiotic)

The emergence of multi-drug resistance among pathogenic bacteria reduces the effect of antibiotics. Therefore, the way antibiotics are administered has begun to change. The antimicrobial resistance crisis is also due to the lack of new drugs. Due to resistance to antibiotics worldwide, interest in old drugs that are not used due to toxic side effects has started to increase again. Therefore, extensive efforts are made to minimize the rate of resistance by examining emerging microorganisms and to optimize the use of legacy antimicrobial agents that can maintain susceptibility profiles.

Chloramphenicol is a new antibiotic widely used in the treatment and prevention of superficial eye infections due to its broad spectrum of activity and beneficial antimicrobial properties such as antibiofilm properties. Chloramphenicol is effective against many pathogenic bacteria and mycoplasma, and it shows its effect by disrupting protein synthesis in the microorganism.

Chloramphenicol is a semi-synthetic, broad-spectrum antibiotic derived mainly from Streptomyces venequelae with bacteriostatic activity. It blocks bacterial protein synthesis and inhibits bacterial cell proliferation.

Chloramphenicol cannot be recommended as first-line therapy for respiratory infections, meningitis, or enteric fever, as its alternatives are probably more effective. Chloramphenicol is as safe as treatment alternatives for short courses of antibiotics.

Large amounts of antibiotics used in human treatment as well as for livestock and even fish in aquaculture have resulted in the selection of multidrug-resistant pathogenic bacteria. Multidrug resistance in bacteria occurs by one of two mechanisms:

• First, these bacteria can accumulate multiple genes within a single cell, each encoding resistance to a single drug. This accumulation typically occurs in resistance plasmids.
• Second, multidrug resistance can occur through increased expression of genes encoding multidrug efflux pumps that extrude a wide variety of drugs.

Multidrug-resistant organisms are bacteria that have become resistant to certain antibiotics, and these antibiotics can no longer be used to control or kill bacteria. Antibiotics are important drugs. They help fight infections caused by bacteria. Bacteria that resist treatment with more than one antibiotic are called multidrug-resistant organisms. These organisms are commonly found in hospitals and long-term care facilities.

Our organization also provides chloramphenicol analysis (antibiotic) services with its trained and expert staff and advanced technological equipment, among the numerous test, measurement, analysis and evaluation studies it provides for businesses in various sectors.