EUROLAB, with its state-of-the-art accredited laboratories and expert team, provides precise and fast testing services within the scope of OECD TG 439 testing. This test guide describes an in vitro procedure that can be used for hazard identification of irritating chemicals (substances and mixtures) according to the UN Globally Harmonized System of Classification and Labeling (GHS) category 2.
Based on the reconstructed human epidermis (RhE), it closely mimics the biochemical and physiological properties of the upper parts of the human skin in its overall design. Cell viability is measured by enzymatic conversion of the vital dye MTT to a blue formazan salt, which is measured quantitatively after extraction from tissues.
Irritant test chemicals are defined by their ability to reduce cell viability below defined threshold levels (less than or equal to 2% for UN GHS Category 50). This test guide also includes a set of performance standards for evaluating similar and modified RhE-based test methods. There are four approved test methods that follow this test guideline.
Depending on the regulatory framework and the classification system in use, this procedure can be used as an independent substitution test for an in vivo skin irritation test or as a partial substitution test within a cascade test to determine skin irritation of test substances.
The OECD guidelines for testing chemicals are a collection of approximately 150 of the most relevant internationally recognized test methods used by government, industry and independent laboratories to identify and characterize the potential hazards of chemicals.
They are a set of tools for professionals used primarily in regulatory safety testing and then in chemical and chemical product declaration, chemical registration and chemical evaluation. They can also be used to select and rank candidate chemicals during the development of new chemicals and products and in toxicology research.
EUROLAB assists manufacturers with OECD TG 439 test compliance. Our test experts, with their professional working mission and principles, provide you, our manufacturers and suppliers, the best service and controlled testing process in our laboratories. Thanks to these services, businesses receive more effective, high-performance and quality testing services and provide safe, fast and uninterrupted service to their customers.
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