EUROLAB laboratory provides testing and compliance services within the scope of OECD 487 standard. The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
The micronucleus may originate from acentric chromosome fragments (ie lacking a centromere) or from whole chromosomes that fail to migrate to the poles during the anaphase stage of cell division.
The test detects the activity of clastogenic and aneugenic test substances in cells that have undergone cell division during or after exposure to the test substance. This Test Guide allows the use of protocols with and without the actin polymerization inhibitor cytochalasin B.
Cytochalasin B allows for the identification and selective analysis of micronucleus frequency in cells that have completed a mitosis because such cells are binucleated. This Test Guideline also permits the use of protocols without cytokinesis blocking, provided there is evidence that the cell population analyzed is undergoing mitosis.
EUROLAB assists manufacturers with OECD 487 test compliance. Our test experts, with their professional working mission and principles, provide you, our manufacturers and suppliers, the best service and controlled testing process in our laboratories. Thanks to these services, businesses receive more effective, high-performance and quality testing services and provide safe, fast and uninterrupted service to their customers.
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