OECD 437 OECD Guidelines for the Testing of Chemicals, Test Method for the Determination of Bovine Corneal Opacity and Permeability

Chemical Tests

OECD 437 OECD Guidelines for the Testing of Chemicals, Test Method for the Determination of Bovine Corneal Opacity and Permeability

EUROLAB laboratory provides testing and compliance services within the scope of OECD 437 standard. The OECD chemicals testing guidelines are a collection of approximately 150 of the most relevant internationally recognized test methods used by government, industry and independent laboratories to identify and characterize the potential hazards of chemicals.

OECD 437 OECD Guidelines for the Testing of Chemicals, Test Method for the Determination of Bovine Corneal Opacity and Permeability

They are a set of tools for professionals used primarily in regulatory safety testing and then in chemical and chemical product declaration, chemical registration and chemical evaluation. They can also be used for selection and sequencing of candidate chemicals during the development of new chemicals and products and in toxicology research. This set of tests covers health effects.

The bovine corneal opacity and permeability test method (BCOP) is an in vitro test method that can be used to identify chemicals (substances or mixtures) 1) as causing "serious eye damage" (category 1 of the globally harmonized system for classification).

BCOP uses corneas isolated from the eyes of commercially slaughtered cattle, thus avoiding the use of laboratory animals. Each treatment group (test chemical, negative/positive controls) consists of at least three eyes with the cornea removed and mounted in a holder.

Depending on the physical nature and chemical properties of the test chemical, different methods can be used for its application, as the critical factor is to ensure that the test chemical adequately covers the epithelial surface.

EUROLAB assists manufacturers with OECD 437 test compliance. Our test experts, with their professional working mission and principles, provide you, our manufacturers and suppliers, the best service and controlled testing process in our laboratories. Thanks to these services, businesses receive more effective, high-performance and quality testing services and provide safe, fast and uninterrupted service to their customers.

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