Chemical Characterization Analysis of Materials (FTIR, LC-MS-MS, SEM, XRD and MALDI TOF Methods)

Material characterization is the process of identifying the chemical properties of one or more components of a substance or material. Characterization techniques are used for a variety of reasons, such as identifying product materials, detecting the presence of impurities and degraders, or establishing a chemical profile of an unknown formulation. Characterization is an important first step before performing a more intensive impurity identification study by removing some variables from the study.

In advanced laboratories, characterization analyzes are carried out for various materials and products. These analyzes help businesses overcome analytical challenges for both medical devices and pharmaceutical products.

Medical device characterization for an apparatus and other related components is carried out in accordance with the ISO 10993 standard (ISO 10993 Biological evaluation of medical devices).

Generally, but not limited to, the following materials are characterized: medical devices, pharmaceuticals, pharmaceutical products, impurities and degraders, excipients, residual solvents, polymers, metals, ceramics, composites, packaging materials and new materials.

The main methods applied in the chemical characterization analyzes of materials are:

• The FTIR (Fourier transform infrared spectroscopy) method is an analytical technique used to identify organic, polymeric and in some cases inorganic materials. This method uses infrared light to scan test samples and observe chemical properties.
• The LC-MS-MS (liquid chromatography - mass spectrometry) method is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry and is popular in chemical analysis.
• SEM (scanning electron microscopy analysis) is a powerful analytical technique for performing analysis at high magnifications and producing high resolution images on a wide variety of materials.
• XRD (X-ray diffraction analysis) is a non-destructive analysis technique that provides detailed information about a material's crystallographic structure, chemical composition, and physical properties.
• The MALDI TOF (Matrix assisted laser desorption/ionization time of flight) method is a widely used technique in the clinical microbiology laboratory for the rapid and accurate identification of bacteria, mycobacteria and certain fungal pathogens.

Among the numerous test, measurement, analysis and evaluation studies it provides for businesses in various sectors, our organization also provides chemical characterization analysis services of materials with its trained and expert staff and advanced technological equipment.